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KMID : 0974620000180020089
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Bulletin of Dongnam Health University
2000 Volume.18 No. 2 p.89 ~ p.94
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The Effects of Bisphenol A on Uterime Smooth Muscle Contraction of the Rat
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Abstract
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Environmental estrogens(xenoestrogens) are a diverse group of chemicals that mimic estrogenic actions. Bisphenol A(BPA), a monomer of plastics used in many consumer products, has estrogenic activity. The overall objective was to examine the effects of BPA on uterine smooth muscle contraction of the rat. High KCI(40 mM) increased the contraction in longitudinal myometrial strips isolated from pregnant and non-pregnant rats. BPA alone had no effect on the resting muscle. But BPA(10 mM) blocked the effect of high KCI by about 50% and 100 mM BPA abolished the contractions elicited by oxytocin(10 nM). Also, the contractile effect of oxytocin was inhibited by pretreatment with the BPA(10 mM) . However, the effects of BPA did not differ significantly between pregnant and non-pregnant myometrium. These results suggest the BPA has effects on the high K+- and oxytocin-induced contractions of the rat uterine smooth muscle.
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